Lack of specificity of progenitor responses to injury in regeneration. Cecilia E. Pellegrini, Peter W. Reddien. bioRxiv 2026
Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration. Kutay Deniz Atabay, Patrick Aoude, Chanyoung Park, Mykola Kadobianskyi, Olivier H. Paugois, Benjamin Judkewitz, Peter W. Reddien. bioRxiv 2026
map3k1 is required for spatial restriction of progenitor differentiation in planarians. Canales BI, King HO, Reddien PW. eLife. 2026
Spatial gene expression maps in vertebrate limbs display conserved and regenerative species-specific features within connective tissue. Conor L. McMann, Chanyoung Park, Jennifer K. Cloutier, Peter W. Reddien. bioRxiv 2025
The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning. Maybrun CL, Oderberg IM, Gaviño MA, Cooke TF, Choi K, Han J, Reddien PW. PLoS Biology. 2025
egal-1 and microtubules promote regeneration polarity in planarians. Miliard Y, Moreno S, Cote LE, Reddien PW. Development. 2025
Coordinated neuron-glia regeneration through Notch signaling in planarians 2025 ML Scimone, BII Canales, P Aoude, KD Atabay, PW Reddien PLoS genetics 21 (1), e1011577
Reduced adult stem cell fate specification led to eye reduction in cave planarians 2025 LO Saad, TF Cooke, KD Atabay, PW Reddien, FD Brown Nature Communications 16 (1), 304
Agelessness is possible under the disposable soma theory but system complexity makes it unlikely 2024 CW Rodriguez, PW Reddien Journal of Theoretical Biology 595, 111958
The pro-apoptotic function of the C. elegans BCL-2 homolog CED-9 requires interaction with the APAF-1 homolog CED-4 2024 N Tucker, P Reddien, B Hersh, D Lee, MHX Liu, HR Horvitz Science Advances 10 (41), eadn0325
The purpose and ubiquity of turnover 2024 PW Reddien Cell 187 (11), 2657-2681
A transcription factor atlas of stem cell fate in planarians 2024 HO King, KE Owusu-Boaitey, CT Fincher, PW Reddien Cell reports 43 (3)
Fate specification is spatially intermingled across planarian stem cells 2023 C Park, KE Owusu-Boaitey, GM Valdes, PW Reddien Nature communications 14 (1), 7422
m6A is required for resolving progenitor identity during planarian stem cell differentiation 2022 Y Dagan, Y Yesharim, AR Bonneau, T Frankovits, S Schwartz, … The EMBO journal 41 (21), e109895
A Krüppel-like factor is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians 2022 M Issigonis, AB Redkar, T Rozario, UW Khan, R Mejia-Sanchez, … PLoS Biology 20 (7), e3001472
The planarian wound epidermis gene equinox is required for blastema formation in regeneration 2022 ML Scimone, JK Cloutier, CL Maybrun, PW Reddien Nature communications 13 (1), 2726
Positional information and stem cells combine to result in planarian regeneration 2022 PW Reddien Cold Spring Harbor Perspectives in Biology 14 (4), a040717
Principles of regeneration revealed by the planarian eye 2021 PW Reddien Current opinion in cell biology 73, 19-25
Planarian stem cells specify fate yet retain potency during the cell cycle 2021 AA Raz, O Wurtzel, PW Reddien Cell stem cell 28 (7), 1307-1322. e5
activin-2 is required for regeneration of polarity on the planarian anterior-posterior axis 2021 JK Cloutier, CL McMann, IM Oderberg, PW Reddien PLoS genetics 17 (3), e1009466
Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration 2020 ML Scimone, KD Atabay, CT Fincher, AR Bonneau, DJ Li, PW Reddien Science 368 (6498), eaba3203
Supplemental Tables for Comprehensive single-cell transcriptional profiling of the regenerative planarian Schmidtea mediterranea 2020 CT Fincher, O Wurtzel, T de Hoog, KM Kravarik, P Reddien
A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels 2019 AG Tewari, JH Owen, CP Petersen, DE Wagner, PW Reddien PLoS genetics 15 (10), e1008401
Cooling through particle loss 2019 J Stajic Science 365 (6452), 459-460
The cells of regeneration 2019 PW Reddien Science 365 (6451), 314-316
Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis 2019 DJ Li, CL McMann, PW Reddien Elife 8, e42015
Muscle functions as a connective tissue and source of extracellular matrix in planarians 2019 LE Cote, E Simental, PW Reddien Nature communications 10 (1), 1592
Acoel genome reveals the regulatory landscape of whole-body regeneration 2019 AR Gehrke, E Neverett, YJ Luo, A Brandt, L Ricci, RE Hulett, A Gompers, … Science 363 (6432), eaau6173
foxF-1 controls specification of non-body wall muscle and phagocytic cells in planarians 2018 ML Scimone, O Wurtzel, K Malecek, CT Fincher, IM Oderberg, … Current Biology 28 (23), 3787-3801. e6
Cellular and molecular responses unique to major injury are dispensable for planarian regeneration 2018 AG Tewari, SR Stern, IM Oderberg, PW Reddien Cell reports 25 (9), 2577-2590. e3
The cellular and molecular basis for planarian regeneration 2018 PW Reddien Cell 175 (2), 327-345
Clonal analysis of planarian stem cells by subtotal irradiation and single-cell transplantation 2018 IE Wang, DE Wagner, PW Reddien Planarian Regeneration: Methods and Protocols, 479-495
Cell type transcriptome atlas for the planarian Schmidtea mediterranea 2018 CT Fincher, O Wurtzel, T de Hoog, KM Kravarik, PW Reddien Science 360 (6391), eaaq1736
Self-organization and progenitor targeting generate stable patterns in planarian regeneration 2018 KD Atabay, SA LoCascio, T de Hoog, PW Reddien Science 360 (6387), 404-409
Orthogonal muscle fibres have different instructive roles in planarian regeneration 2017 ML Scimone, LE Cote, PW Reddien Nature 551 (7682), 623-628
Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning 2017 AA Raz, M Srivastava, R Salvamoser, PW Reddien Nature communications 8 (1), 1260
Planarian epidermal stem cells respond to positional cues to promote cell-type diversity 2017 O Wurtzel, IM Oderberg, PW Reddien Developmental cell 40 (5), 491-504. e5
Landmarks in existing tissue at wounds are utilized to generate pattern in regenerating tissue 2017 IM Oderberg, DJ Li, ML Scimone, MA Gaviño, PW Reddien Current Biology 27 (5), 733-742
Eye absence does not regulate planarian stem cells during eye regeneration 2017 SA LoCascio, SW Lapan, PW Reddien Developmental Cell 40 (4), 381-391. e3
Acoel regeneration mechanisms indicate ancient and widespread role for muscle in regenerative patterning. 2017 AA Raz, M Srivastava, PW Reddien MOLECULAR BIOLOGY OF THE CELL 28
Orchestrating regeneration: orthogonal subsets of muscle fibers have different instructive roles in restoring the planarian body plan. 2017 LE Cote, ML Scimone, PW Reddien MOLECULAR BIOLOGY OF THE CELL 28
Genetic characterization of planarian poles identifies nr4A as a muscle transcription factor that maintains patterning in the head and tail 2017 D Li, P Reddien Mechanisms of Development, S77
Editorial overview: Cell reprogramming, regeneration and repair. 2016 PW Reddien, EM Tanaka Current Opinion in Genetics & Development 40, iv-vi
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes 2016 MA Carmell, GA Dokshin, H Skaletsky, YC Hu, JC van Wolfswinkel, … Elife 5, e19993
Hedgehog signaling regulates gene expression in planarian glia 2016 IE Wang, SW Lapan, ML Scimone, TR Clandinin, PW Reddien Elife 5, e16996
Two FGFRL-Wnt circuits organize the planarian anteroposterior axis 2016 ML Scimone, LE Cote, T Rogers, PW Reddien Elife 5, e12845
Methods Of Modifying A Sequence Using CRISPR 2016 O Wurtzel, S LoCascio, P Reddien US Patent App. 14/801,133
Methods Of Depleting Target Sequences Using CRISPR 2016 O Wurtzel, S LoCascio, P Reddien US Patent App. 14/802,886
A generic and cell-type-specific wound response precedes regeneration in planarians 2015 O Wurtzel, LE Cote, A Poirier, R Satija, A Regev, PW Reddien Developmental cell 35 (5), 632-645 Peter Reddien 2015 P Reddien Current Biology 25 (18), R779-R780
teashirt is required for head-versus-tail regeneration polarity in planarians 2015 JH Owen, DE Wagner, CC Chen, CP Petersen, PW Reddien Development 142 (6), 1062-1072
Neoblast Specialization in the Nervous System of the Planarian Schmidtea mediterranea 2015 KM Kravarik, PW Reddien MOLECULAR BIOLOGY OF THE CELL 26
Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment 2014 JC Van Wolfswinkel, DE Wagner, PW Reddien Cell stem cell 15 (3), 326-339
Neoblast specialization in regeneration of the planarian Schmidtea mediterranea 2014 ML Scimone, KM Kravarik, SW Lapan, PW Reddien Stem cell reports 3 (2), 339-352
Methods for identifying candidate modulators of NOTUM activity 2014 P Reddien, C Petersen US Patent 8,802,365
Whole-body acoel regeneration is controlled by Wnt and Bmp-Admp signaling 2014 M Srivastava, KL Mazza-Curll, JC van Wolfswinkel, PW Reddien Current biology 24 (10), 1107-1113
A forkhead Transcription Factor Is Wound-Induced at the Planarian Midline and Required for Anterior Pole Regeneration 2014 ML Scimone, SW Lapan, PW Reddien PLoS genetics 10 (1), e1003999
Heterogeneity in planarian neoblasts by single cell analysis 2014 JC Van Wolfswinkel, DE Wagner, PW Reddien INTEGRATIVE AND COMPARATIVE BIOLOGY 54, E214-E214
Molecular mechanisms for whole-body regeneration in acoels 2014 M Srivastava, KM Mazza-Curll, P Reddien INTEGRATIVE AND COMPARATIVE BIOLOGY 54, E199-E199
Lin28: time for tissue repair 2013 PW Reddien Cell 155 (4), 738-739
Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling 2013 MA Gaviño, D Wenemoser, IE Wang, PW Reddien Elife 2, e00247
Muscle cells provide instructions for planarian regeneration 2013 JN Witchley, M Mayer, DE Wagner, JH Owen, PW Reddien Cell reports 4 (4), 633-641
Specialized progenitors and regeneration 2013 PW Reddien Development 140 (5), 951-957
pbx is required for pole and eye regeneration in planarians 2013 CCG Chen, IE Wang, PW Reddien Development 140 (4), 719-729
Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration 2012 SW Lapan, PW Reddien Cell reports 2 (2), 294-307
A molecular wound response program associated with regeneration initiation in planarians 2012 D Wenemoser, SW Lapan, AW Wilkinson, GW Bell, PW Reddien Genes & development 26 (9), 988-1002
A comparative approach to animal regeneration 2012 M Srivastava, PW Reddien INTEGRATIVE AND COMPARATIVE BIOLOGY 52, E166-E166
The cellular and molecular basis for planarian regeneration 2012 P Reddien The FASEB Journal 26, 84.3-84.3
Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis 2012 DE Wagner, JJ Ho, PW Reddien Cell stem cell 10 (3), 299-311
A regulatory program for excretory system regeneration in planarians 2011 ML Scimone, M Srivastava, GW Bell, PW Reddien Development 138 (20), 4387-4398
dlx and sp6-9 Control Optic Cup Regeneration in a Prototypic Eye 2011 SW Lapan, PW Reddien PLoS genetics 7 (8), e1002226
The cellular basis for animal regeneration 2011 EM Tanaka, PW Reddien Developmental cell 21 (1), 172-185
Constitutive gene expression and the specification of tissue identity in adult planarian biology 2011 PW Reddien Trends in Genetics 27 (7), 277-285
Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration 2011 CP Petersen, PW Reddien Science 332 (6031), 852-855
Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration 2011 DE Wagner, IE Wang, PW Reddien Science 332 (6031), 811-816
A Bmp/Admp regulatory circuit controls maintenance and regeneration of dorsal-ventral polarity in planarians 2011 MA Gaviño, PW Reddien Current Biology 21 (4), 294-299
Planarian regeneration involves distinct stem cell responses to wounds and tissue absence 2010 D Wenemoser, PW Reddien Developmental biology 344 (2), 979-991
The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea 2010 ML Scimone, J Meisel, PW Reddien Development 137 (8), 1231-1241
The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis 2010 AM Glazer, AW Wilkinson, CB Backer, SW Lapan, JH Gutzman, … Developmental biology 337 (1), 148-156
Wnt signaling and the polarity of the primary body axis 2009 CP Petersen, PW Reddien Cell 139 (6), 1056-1068
A wound-induced Wnt expression program controls planarian regeneration polarity 2009 CP Petersen, PW Reddien Proceedings of the National Academy of Sciences 106 (40), 17061-17066
Gene nomenclature guidelines for the planarian Schmidtea mediterranea 2008 PW Reddien, PA Newmark, AS Alvarado Developmental Dynamics: An Official Publication of the American Association …
Smed-βcatenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration 2008 CP Petersen, PW Reddien Science 319 (5861), 327-330
BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration 2007 PW Reddien, AL Bermange, AM Kicza, A Sánchez Alvarado Oxford University Press for The Company of Biologists Limited 134 (22), 4043 …
DPL-1 DP, LIN-35 Rb and EFL-1 E2F Act With the MCD-1 Zinc-Finger Protein to Promote Programmed Cell Death in Caenorhabditis elegans 2007 PW Reddien, EC Andersen, MC Huang, HR Horvitz Genetics 175 (4), 1719-1733
Methods and compositions for RNA interference 2007 A Alvarado, P Reddien, A Bermange US Patent App. 11/413,795
Methods and compositions for RNA interference 2007 AS Alvarado, PW Reddien, AL Bermange WO2005047300
INVESTIGATIONS-Developmental and behavioral genetics-DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis … 2007 PW Reddien, EC Andersen, MC Huang, HR Horvitz Genetics 175 (4), 1719-1734
SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells 2005 PW Reddien, NJ Oviedo, JR Jennings, JC Jenkin, AS Alvarado Science 310 (5752), 1327-1330
Stem cell and regeneration regulators in the planarian Schmidtea mediterranea. 2005 AS Alvarado, PW Reddien, A Bermange, K Murfitt, JR Jennings DEVELOPMENTAL BIOLOGY 283 (2), 581-581
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria 2005 PW Reddien, AL Bermange, KJ Murfitt, JR Jennings, AS Alvarado Developmental cell 8 (5), 635-649
Stem cell regulation in the planarian Schmidtea mediterranea 2004 PW Reddien, A Bermange, K Murffit, G Eisenhoffer, NJ Oviedo, J Robb, … Molecular Biology of the Cell 15, 361A-361A
THE ENGULFMENT PROCESS OF PROGRAMMED CELL DEATH IN CAENORHABDITIS ELEGANS 2004 PW Reddien, HR Horvitz Annu. Rev. Cell Dev. Biol. 20, 193-221
Fundamentals of planarian regeneration 2004 PW Reddien, AS Alvarado Annu. Rev. Cell Dev. Biol. 20, 725-757
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians 2003 PA Newmark, PW Reddien, F Cebria, AS Alvarado Proceedings of the National Academy of Sciences 100 (suppl_1), 11861-11865
Functional studies of regeneration in the planarian Schmidtea mediterranea. 2003 AS Alvarado, PW Reddien, A Bermange, N Oviedo, SMC Robb Developmental Biology 259 (2), 525-525
An RNAi screen for regeneration genes in the planarian, Schmidtea mediterranea. 2003 AL Bermange, PW Reddien, AS Alvarado DEVELOPMENTAL BIOLOGY 259 (2), 536-536
Phagocytosis promotes programmed cell death and is controlled by a Rac signaling pathway in Caenorhabditis elegans. 2003 PW Reddien
Phagocytosis promotes programmed cell death and is controlled by Rac signaling pathway in C. elegans 2002 PW Reddien Massachusetts Institute of Technology
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis 2001 EA Lundquist, PW Reddien, E Hartwieg, HR Horvitz, CI Bargmann Oxford University Press for The Company of Biologists Limited 128 (22), 4475 …
Phagocytosis promotes programmed cell death in C. elegans 2001 PW Reddien, S Cameron, HR Horvitz Nature 412 (6843), 198-202
Differential roles of Rac GTPases in axon pathfinding and cell corpse phagocytosis in Caenorhabditis elegans. 2001 EA Lundquist, P Reddien, E Hartwieg, HR Horvitz, CI Bargmann DEVELOPMENTAL BIOLOGY 235 (1), 175-175
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans 2000 PW Reddien, HR Horvitz Nature cell biology 2 (3), 131-136
Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3 1999 S Shaham, PW Reddien, B Davies, HR Horvitz Genetics 153 (4), 1655-1671 251
Demography, kinship, and the evolving theory of genomic imprinting F Úbeda, JF Wilkins, JT Anderson, JH Willis, T Mitchell-Olds, W Wei, …
Smed-β catenin-Regeneration CP Petersen, PW Reddien