Publications

Aneesha G. Tewari, Jared H. Owen, Christian P. Petersen, Daniel E. Wagner, and Peter W. Reddien. A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels. PLoS Genetics 15(10):e1008401, 2019.

Peter W. Reddien. The cells of regeneration. Science. 365(6451):314-316, 2019.

Dayan J. Li, Conor L. McMann, Peter W. Reddien. Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis. eLife. 8:e42015. 2019.

Lauren E. Cote, Eric Simental, Peter W. Reddien. Muscle functions as a connective tissue and source of extracellular matrix in planarians. Nature Communications. 10(1):1592, 2019.

Andrew R. Gehrke, Emily Neverett, Yi-Jyun Luo, Alexander Brandt, Lorenzo Ricci, Ryan E. Hulett, Annika Gompers, J. Graham Ruby, Daniel S. Rokhsar, Peter W. Reddien, Mansi Srivastava. Acoel genome reveals the regulatory landscape of whole-body regeneration. Science. 2019 Mar 15;363(6432).

Aneesha G. Tewari, Sarah R. Stern, Isaac M. Oderberg, Peter W. Reddien. Cellular and molecular responses unique to major injury are dispensable for planarian regeneration. Cell Reports 25(9):2577-2590, 2018

M. Lucila Scimone1, Omri Wurtzel1, Kathryn Malecek, Christopher T. Fincher, Isaac M. Oderberg, Kellie M. Kravarik, Peter W. Reddien. foxF-1 controls specification of non-body wall muscle and phagocytic cells in planarians. Current Biology. 28(23):3787-3801, 2018

Peter W. Reddien. The cellular and molecular basis for planarian regeneration. Cell, 175(2):327-345, 2018

Irving E. Wang1, Daniel E. Wagner1, and Peter W. Reddien. Clonal Analysis of Planarian Stem Cells by Subtotal Irradiation and Single-Cell Transplantation. Methods Mol Biol. 1774:479-495, 2018

Christopher T. Fincher, Omri Wurtzel, Thom de Hoog, Kellie M. Kravarik, and Peter W. Reddien. Cell type transcriptome atlas for the planarian Schmidtea mediterranea. Science, 360(6391), 2018

Kutay D. Atabay, Samuel A. LoCascio, Thom de Hoog, and Peter W. Reddien. Self-organization and progenitor targeting generate stable patterns in planarian regeneration. Science, 360(6387): 404-409, 2018

M. Lucila Scimone, Lauren E. Cote, Peter W. Reddien. Orthogonal muscle fibres have different instructive roles in planarian regeneration. Nature, 551, 623-628, 2017

Amelie A. Raz, Mansi Srivastava, Ranja Salvamoser, and Peter W. Reddien. Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning. Nature Communications, 8(1):1260, 2017

Omri Wurtzel1, Isaac M. Oderberg1, and Peter W. Reddien. Planarian epidermal stem cells respond to positional cues to promote cell type diversity. Developmental Cell, 40, 491-504, 2017

Samuel A. LoCascio, Sylvain W. Lapan, and Peter W. Reddien. Eye absence does not regulate planarian stem cells during eye regeneration. Developmental Cell, 40, 381–391, 2017

Isaac M. Oderberg, Dayan J. Li, M. Lucila Scimone, Michael A. Gaviño, and Peter W. Reddien. Landmarks in existing tissue at wounds are utilized to generate pattern in regenerating tissue. Current Biology, 27, 733-742, 2017

Peter W. Reddien, Elly M. Tanaka. Editorial overview: Cell reprogramming, regeneration and repair. Curr Opin Genet Dev. 40:iv-vi, 2016

Michelle A. Carmell, Gregoriy A. Dokshin, Helen Skaletsky, Yueh-Chiang Hu, Josien C. van Wolfswinkel, Kyomi J. Igarashi, Daniel W. Bellott, Michael Nefedov, Peter W. Reddien, George C. Enders, Vladimir N. Uversky, Craig C. Mello, David C. Page. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. eLife 5:e19993, 2016

Irving E. Wang1, Sylvain W. Lapan1, M. Lucila Scimone, Thomas R. Clandinin, Peter W. Reddien. Hedgehog signaling regulates gene expression in planarian glia. eLife 5:e16996, 2016.

M. Lucila Scimone1, Lauren E. Cote1, Travis Rogers, and Peter W. Reddien. Two FGFRL-Wnt circuits organize the planarian anteroposterior axis. eLife 5:e12845, 2016.

Omri Wurtzel, Lauren E. Cote, Amber Poirier, Rahul Satija, Aviv Regev, Peter W. Reddien. A generic and cell-type-specific wound response precedes regeneration in planarians. Developmental Cell 35, 632-45, 2015.

Jared H. Owen1, Daniel E. Wagner1, Christian P. Petersen, and Peter W. Reddien. teashirt is required for anteroposterior polarity regeneration in planarians. Development, 142, 1062-72, 2015.

M. Lucila Scimone1, Kellie M. Kravarik1, Sylvain W. Lapan1, and Peter W. Reddien. Neoblast specialization in regeneration of the planarian Schmidtea mediterranea. Stem Cell Reports, 3, 339-352, 2014.

Josien C. van Wolfswinkel1, Daniel E. Wagner1, and Peter W. Reddien. Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment. Cell Stem Cell, 15, 1-14, 2014.

Mansi Srivastava, Kathleen L. Mazza-Curll, Josien C. van Wolfswinkel, and Peter W. Reddien. Whole-body acoel regeneration is controlled by Wnt and Bmp-Admp signaling. Current Biology, 24, 1107-1113, 2014.

M. Lucila Scimone, Sylvain W. Lapan, and Peter W. Reddien. A forkhead transcription factor is wound-induced at the planarian midline and required for anterior pole regeneration. PLoS Genetics, 10(1):e1003999, 2014.

Peter W. Reddien. Lin28: time for tissue repair. Cell, 155, 738-739, 2013.

Michael A. Gavino1, Danielle Wenemoser1, Irving E. Wang, and Peter W. Reddien. Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling. eLife 2:e00247, 2013.

Jessica N. Witchley1, Mirjam Mayer1, Daniel E. Wagner, Jared H. Owen, and Peter W. Reddien. Muscle cells provide instructions for planarian regeneration. Cell Reports, 4(4): 633-41, 2013.

Peter W. Reddien. Specialized progenitors and regeneration. Development, 140, 951-957, 2013.

Chun-Chieh G. Chen, Irving E. Wang, and Peter W. Reddien. pbx is required for pole and eye regeneration in planarians. Development, 140, 719-729 (2013)

Sylvain W. Lapan and Peter W. Reddien. Transcriptome analysis of a simple eye identifies ovo as a specific regulator of eye regeneration. Cell Reports 2(2): 294-307 (2012)

Danielle Wenemoser, Sylvain W. Lapan, Alex W. Wilkinson, George W. Bell, and Peter W. Reddien. A molecular wound response program associated with regeneration initiation in planarians. Genes and Development, 26(9): 988-1002 (2012)

Daniel E. Wagner, Jaclyn J. Ho, and Peter W. Reddien. Genetic regulators of adult pluripotent stem cells identified by RNAi and clonal analysis in planarians. Cell Stem Cell 10, 299-311 (2012)

M. Lucila Scimone, Mansi Srivastava, George W. Bell, and Peter W. Reddien. A regulatory program for excretory system regeneration in planarians. Development 138, 4387-4398 (

Sylvain Lapan and Peter W. Reddien. dlx and sp6-9 control optic cup regeneration in a prototypic eye. PLoS Genetics 7(8), e1002226 (2011)

Elly M. Tanaka and Peter W. Reddien. The cellular basis for animal regeneration. Developmental Cell 21, 172-185 (2011)

Peter W. Reddien. Constitutive gene expression and the specification of tissue identity in adult planarian biology. Trends in Genetics 27(7), 277-285 (2011)

Daniel E. Wagner1, Irving E. Wang1, and Peter W. Reddien. Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science 332, 811-816(2011)

Christian P. Petersen and Peter W. Reddien. Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration. Science 332, 852-855(2011)

Michael A. Gavino and Peter W. Reddien. A Bmp/Admp regulatory circuit controls maintenance and regeneration of dorsal-ventral polarity in planarians. Current Biology 21, 1-6 (2011)

Danielle Wenemoser and Peter W. Reddien. Planarian regeneration involves distinct stem cell responses to wounds and tissue absence. Developmental Biology, 344, 979-991 (2010)

M. Lucila Scimone and Peter W. Reddien. The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea. Development, 137, 1231-1241 (2010)

Andrew M. Glazer, Alex W. Wilkinson, Chelsea B. Backer, Sylvain W. Lapan, Jennifer Gutzman, Iain M. Cheeseman, and Peter W. Reddien. The Zn Finger Iguana protein controls ciliogenesis. Developmental Biology 337(1), 148-156 (2010)

Christian P. Petersen and Peter W. Reddien. Wnt signaling and the polarity of the primary body axis. Cell, 139, 1056-1068 (2009)

Christian P. Petersen and Peter W. Reddien. A wound-induced Wnt expression program controls planarian regeneration polarity. PNAS, 106(40), 17061-6 (2009)

Peter W. Reddien, Phillip A. Newmark, and Alejandro Sánchez Alvarado. Gene nomenclature guidelines for the planarian Schmidtea mediterranea.  Developmental Dynamics 237, (2008)

Christian P. Petersen and Peter W. Reddien. Smed-bcatenin-1 is required for anteroposterior blastema polarity in planarian regeneration. Science 319, 327-30 (2008)

Peter W. Reddien, Adam L. Bermange, Adrienne M. Kicza, Alejandro Sánchez Alvarado.  BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development, 134, 4043-4051 (2007)

Peter W. Reddien, Erik C. Andersen, and H. Robert Horvitz. DPL-1DP, LIN-35 Rb, and EFL-1 E2F act together with thhttps://www.genetics.org/content/175/4/1719.longe MCD-1 Zinc-finger protein to promote programmed cell death in C. elegans. Genetics 175, 1719-1733 (2007)

Peter W. Reddien, Néstor J. Oviedo, Joya R. Jennings, James C. Jenkin, and Alejandro Sánchez Alvarado.  SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.  Science 310, 1327-1330 (2005)

Peter W. Reddien, Adam L. Bermange, Kenneth J. Murfitt, Joya Robb, and Alejandro Sánchez Alvarado.  Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Developmental Cell 8, 635-49 (2005)

Peter W. Reddien and Alejandro Sánchez Alvarado. Fundamentals of planarian regeneration. Ann. Review Cell and Dev. Bio. 20, 735-757 (2004)

Peter W. Reddien and H. Robert Horvitz. The engulfment process of programmed cell death in Caenorhabditis elegans. Ann. Review Cell and Dev. Bio. 20, 193-221 (2004)

Phillip A. Newmark, Peter W. Reddien, Francesc Cébria, Alejandro Sánchez Alvarado. Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planariansPNAS 100, 11861-5 (2003)

Erik Lundquist1, Peter W. Reddien1, Erika Hartwieg, H. Robert Horvitz, and Cornelia Bargmann.  Three C. elegans Rac genes and several alternative Rac regulators control axon guidance, cell migration, and apoptotic cell phagocytosis.  Development, 128, 4475-4488 (2001)

Peter W. Reddien, Scott Cameron, and H. Robert Horvitz.  Phagocytosis promotes programmed cell death in C. elegans. Nature 412, 198-202 (2001)

Peter W. Reddien and H. Robert Horvitz. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nature Cell Biology 2, 131-136 (2000)

Shai Shaham, Peter W. Reddien, Brian Davies, and H. Robert Horvitz. Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. Genetics 153, 1655-1671 (1999)

1 equal contribution